The National Library of Medicine (NLM), on the campus of the National Institutes of Health in Bethesda, Maryland is a leader in medical informatics and computational biology research. Training opportunities are offered at the NLM Intramural Research Program (IRP), which develops and applies computational approaches to a broad range of information problems in biology, biomedicine, and human health. In computational health research, the focus areas include natural language processing, clinical image processing, biomedical ontologies and information models, and clinical analytics. In Computational biology research, topics include transcription, chromatin and networks; structure and function; sequence statistics; and evolutionary genomics.